Recent Articles on Pancreatobiliary #Pathology – 2020-10-29

These are the recent articles on Pancreatobiliary Pathology:

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New Pancreas Articles

  • Age is in the eye of the beholder: Distinguishing molecular signatures in early-onset pancreatic adenocarcinomas

Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Oct;():


Pancreatic adenocarcinoma (PDAC) is more prevalent in older patients, but early-onset cases (<55 years) may be a distinct genetic subpopulation. Differential expression of CDKN2A and transcription factor FOXC2 were found in early-onset cases. This finding opens the door to investigating additional features that distinguish PDAC tumors in this age group.


  • Pilot study examining the impact of a specialist multidisciplinary team clinic for patients with chronic pancreatitis

Pancreatology : official journal of the International Association of Pancreatology (IAP) … [et al.] 2020 Oct;():


OBJECTIVE: -To assess the efficacy of a pilot Chronic Pancreatitis (CP) Multidisciplinary (MDT) clinic.
METHODS: – 60 patients referred to a pilot MDT CP clinic were analysed. Anthropometric data, nutrition status, malabsorption evidence, glycaemic control, opiate use, bone mineral density (BMD) assessment and quality of life (QoL) were examined.
RESULTS: -The average age was 51.27 (±12.75). The commonest aetiology was alcohol (55%). Ninety one point five percent had evidence of ongoing pancreatic exocrine insufficiency, with 88.1% requiring initiation or up-titration of pancreatic enzyme replacement (PERT). Up to half of the patients exhibited micronutrient deficiency. Twenty eight percent were diagnosed with type IIIc diabetes. There was an average daily reduction of 6 mg of morphine usage per patient with a concurrent decline in median pain scores from 83.3 to 63.3, which was non-significant. The median QoL score was 33.3 compared to a score of 75 from the reference population. QoL scores increased from 31.0 to 37.3 at follow up appointments. Seventy two point five percent of patients had undiagnosed low BMD.
CONCLUSION: The data suggest that CP patients have significant nutritional deficiencies as well as undiagnosed diabetes, poor pain and glycaemic control which negatively impacts QoL. Assessment in a multi-disciplinary clinic ensures appropriate management.


New GallBladder Articles

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New BileDuct Articles

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New Ampulla Articles

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