Case

Normal colonic mucosa can mimic prostate adenocarcinoma morphologically with rows of small glands with cells with large nuclei, prominent nucleoli, and amphophilic cytoplasm. Note that they lack goblet cells due to procedural compression. These glands stain like prostate cancer with a triple stain (PIN4), showing diffuse staining for arginase (red) and lack of staining for p63 and HMWCK. The key to avoiding this morphological and immunohistochemical pitfall is to identify the lamina propria (arrow) surrounding the colonic glands. Additionally, positive CDX2 immunostaining confirms the intestinal origin of the glands.

Source: Case

Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma – PubMed

Entosis is a type of regulated cell death that promotes cancer cell competition. Though several studies have revealed the molecular mechanisms that govern entosis, the clinical and genetic correlates of entosis in human tumors is less well understood. Here we reviewed entotic cell-in-cell (CIC) patt …

Source: Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma – PubMed

Registration to the most awaited conference-MasterClass in Pathology 2021 is now open. Click on the Events button on https://lnkd.in/dkAYekf to register and start previewing the presentation slides. via Rajendra Singh MD https://www.linkedin.com/posts/rajendra-singh-md-56b17642_master-class-in-pathology-ugcPost-6823587847988097024-SasZ/

Registration to the most awaited conference-MasterClass in Pathology 2021 is now open. Click on the Events button on https://lnkd.in/dkAYekf to register and start previewing the presentation slides. via Rajendra Singh MD


https://www.linkedin.com/posts/rajendra-singh-md-56b17642_master-class-in-pathology-ugcPost-6823587847988097024-SasZ/

Intraductal papillary squamous neoplasm of the pancreas: Cyto-histologic correlation of a novel entity – PubMed

We correlate the cytologic and histologic features of a squamous-lined pancreatic cystic lesion with a complex papillary architecture and an associated KRAS mutation, which to our knowledge has not been previously described. A 69 year-old woman presented with intermittent left upper quadrant pain. C …

Source: Intraductal papillary squamous neoplasm of the pancreas: Cyto-histologic correlation of a novel entity – PubMed